Publications | Ohtani Lab

Original Articles

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Zhang X, Zhang M, Huang S, Ohtani K, Xu L, Guo Y: Engineered Polymeric Nanovector for Intracellular Peptide Delivery in Antitumor Therapy. Int J Nanomedicine. 2023 Sep 19:18:5343-5363. doi: 10.2147/IJN.S427536. eCollection 2023.

Nakajima R, Deguchi R, Komori H, Zhao L, Zhou Y, Shirasawa M, Angelina A, Goto Y, Tohjo F, Nakahashi K, Nakata K, Iwanaga R, Bradford AP, Araki K, Warita T, Ohtani K: The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F. Biochem Biophys Res Commun. 2023 Jun 30;663:154-162. doi: 10.1016/j.bbrc.2023.04.092. Epub 2023 Apr 25. PMID: 37141667

Araki K, Kawauchi K, Sugimoto W, Tsuda D, Oda H, Yoshida R, Ohtani K: Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells. Commun Biol. 2019 Jan 3;2:3. doi: 10.1038/s42003-018-0246-9. eCollection 2019.

Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford P, Araki K and Ohtani K: Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes. Scientific Reports, 2018 May 31;8(1):8438. doi: 10.1038/s41598-018-26860-0.

Kurayoshi K, Shiromoto A, Ozono E, Iwanaga R, Bradford AP, Araki K and Ohtani K: Ectopic expression of CDK inhibitor p21Cip1 enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by ARF tumor suppressor promoter. Biochem Biophys Res Commun, 483, 107-114, 2017 Jan 29;483(1):107-114. doi: 10.1016/j.bbrc.2016.12.185. Epub 2016 Dec 29.

Kurayoshi K, Okuno J, Ozono E, Iwanaga R, Bradford AP, Kugawa K, Araki K, Ohtani K: The phosphatidyl inositol 3 kinase pathway does not suppress activation of the ARF and BIM genes by deregulated E2F1 activity. Biochem Biophys Res Commun, 482, 784-790, 2017. Jan 22;482(4):784-790. doi: 10.1016/j.bbrc.2016.11.111. Epub 2016 Nov 22.

Okuda M, Araki K, Ohtani K, Nishimura Y: The interaction mode of the acidic region of the cell cycle transcription factor DP1 with TFIIH. J Mol Biol. 428, 4993-5006, 2016. Dec 4;428(24 Pt B):4993-5006. doi: 10.1016/j.jmb.2016.11.001. Epub 2016 Nov 5.

Kitamura H, Ozono E, Iwanaga R, Bradford AP, Okuno J, Shimizu E, Kurayoshi K, Kugawa K, Toh H, Ohtani K.: Identification of novel target genes specifically activate by deregulated E2F in human normal fibroblasts. Genes Cells, 20, 739-757, 2015 Sep. doi: 10.1111/gtc.12268. Epub 2015 Jul 23.

Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Komori H, Ohtani K.: Cancer cell specific cytotoxic gene expression mediated by ARF tumor suppressor promoter constructs. Biochem Biophys Res Commun, 450, 240-246, 2014. Jul.18. doi: 10.1016/j.bbrc.2014.05.102. Epub 2014 Jun 2.

Moor K, Ohtani K, Myrzakozha D, Zhanserkenova O, Andriana BB, Sato H: Noninvasive and label-free determination of virus infected cells by Raman spectroscopy. J Biomed Opt, 19, 67003, 2014 Jun 1.

Ozono E, Komori H, Iwanaga R, Tanaka T, Sakae T, Kitamura H, Yamaoka S, Ohtani K.: Tumor suppressor TAp73 gene specifically responds to deregulated E2Factivity in human normal fibroblasts. Genes Cells, 17, 660-672, 2012. Aug.doi: 10.1111/j.1365-2443.2012.01617.x.

Ma, T., Yamada, S., Ichwan, S., Iseki, S., Ohtani, K., Otsu, M., Ikeda, MA.: Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation. Biochem. Biophys. Res. Commun., 417, 931-937, 2012. Jan.

Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S., Ohta, T., Ohtani, K., Kobayashi, M., and Takihara, Y.: Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential. Proc Natl Acad Sci USA, 107, 21529-21534, 2010. Dec.

Ozono, E., Komori, H., Iwanaga, R., Ikeda, MA., Iseki, S., and Ohtani, K.: E2F-like elements in p27Kip1 promoter specifically sense deregulated E2F activity. Genes Cells, 14, 89-99, 2009. Jan.

Iwanaga, R., Ozono, E., Fujisawa, J., Ikeda, MA., Okamura, N., Huang, Y., and Ohtani, K.: Activation of the cyclin D2 and cdk6 genes through NF-kB is critical for cell cycle progression induced by HTLV-I Tax. Oncogene, 27, 5635-5642, 2008. Sept.

Hara, T., Matsumura-Arioka, Y., Ohtani, K., and Nakamura, M.: A role of human T-cell leukemia virus type I Tax in expression of the human telomerase reverse transcriptase gene in human T cells. Cancer Science, 99, 1155-1163, 2008. Jun.

Gohda, J., Irisawa, M., Tanaka, Y., Sato, S., Ohtani, K., Fujisawa, J., Inoue, J.: HTLV-1 Tax-induced NFκB activation is independent of Lys-63-linked-type polyubiquitination. Biochem Biophys Res Commun, 357, 225-230, 2007. May.

Masai, H., Taniyama. C., Ogino, K., Matsui, E., Kakusho, N., Matsumoto, S., Kim, J.M., Ishii, A., Tanaka, T., Kobayashi, T., Tamai, K., Ohtani, K., and Arai, K.: Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. J. Biol. Chem., 281, 39249-39261, 2006.Dec.

Goto, Y., Hayashi, R., Muramatsu, T., Ogawa, H., Eguchi, I., Oshida, Y., Ohtani, K., Yoshida, K.: JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. Biochim Biophys Acta., 1759, 60-68, 2006. Jan.

Iwanaga, R., Komori, H., Ishida, S., Okamura, N., Nakayama, K., Nakayama, K-I. and Ohtani, K.: Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners. Oncogene, 25, 1786-1798, 2006. Mar.

Komori, H., Enomoto, M., Nakamura, M., Iwanaga, R., and Ohtani, K.: Distinct E2F-mediated transcriptional program regulates p14ARF gene expression. EMBO J., 24, 3724-3736, 2005. Nov.

Matsumura-Arioka, Y., Ohtani, K., Hara, T. Iwanaga, R. and Nakamura, M.: Identification of two distinct elements mediating activation of telomerase (hTERT) gene expression in association with cell growth in human T cells. Int. Immunol., 17, 207-215, 2005. Feb.

Iwanaga, R., Komori, H. and Ohtani, K.: Differential regulation of expression of the mammalian DNA repair genes by growth stimulation. Oncogene, 23, 8581-8590, 2004.

Yamada M., Sato N., Taniyama C., Ohtani K., Arai K.I., Masai H.: A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase. J. Biol. Chem., 277, 27668-27681, 2002.

Funato, N., Ohtani, K., Ohyama, K., Kuroda, T. and Nakamura, M.: Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factors. Mol. Cell. Biol., 21, 7416-7428, 2001.

Iwanaga, R., Ohtani, K.＊, Hayashi, T. and Nakamura, M.: Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I. Oncogene, 20, 2055-2067, 2001. (＊Corresponding author)

Huang, Y., Ohtani, K.＊, Iwanaga, R., Matsumura, Y. and Nakamura, M.: Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I. Oncogene, 20, 1094-1102, 2001. (＊Corresponding author)

Iwanaga, R., Ohtani, K.＊ and Nakamura, M.: Requirement of cell growth for gene expression induced by the lactose and tetracycline repressor-operator combination system in a human T cell line. Biochem. Biophys. Res. Commun., 276, 546-552, 2000. (＊Corresponding author)

Chida, T., Okamura, N., Ohtani, K., Yoshida, Y., Arakawa, E., Watanabe, H.: The complete DNA sequence of the O antigen gene region of Plesiomonas shigelloides serotype O17 which is identical to Shigella sonnei form I antigen. Microbiol. Immunol., 44, 161-172, 2000.

Ohtani, K., Iwanaga, R., Arai, M., Huang, Y., Matsumura, Y. and Nakamura, M.: Cell type-specific E2F activation and cell cycle progression by the oncogene product Tax of human T-cell leukemia virus type I. J. Biol. Chem., 275, 11154-11163, 2000.

Arata, Y., Fujita, M., Ohtani, K., Kijima, S. and Kato, J.: Cdk2-dependent and -independent pathways in E2F-mediated S phase induction. J. Biol. Chem., 257, 6337-6345, 2000.

Tsukahara, T., Kannagi, M., Ohashi, T., Kato, H., Arai, M., Nunez, G., Iwanaga, Y., Yamamoto, N., Ohtani, K., Nakamura, M., Fujii, M.: Induction of bcl-xL expression by human T-cell leukemia virus type 1 Tax through NF-kB in apoptosis-resistant T-cell transfectants with Tax. J. Virol., 73, 7981-7987, 1999

Iwanaga, Y., Tsukahara, T., Ohashi, T., Tanaka, Y., Arai, M., Nakamura, M., Ohtani, K., Koya , Y., Kannagi, M., Yamamoto, N. & Fujii, M.: Human T-cell leukemia virus type I Tax protein abrogates interleukin-2 dependence in a mouse T-cell line. J. Virol., 73, 1271-1277, 1999.

Ohtani, K., Iwanaga, R., Nakamura, M., Ikeda, M., Yabuta, N., Tsuruga, H. and Nojima H.: Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. Oncogene, 18, 2299-2309, 1999.

Ohtani, K., Tsujimoto, A., Ikeda, M. and Nakamura, M.: Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F. Oncogene, 17, 1777-1785, 1998.

Ohtani, K., Tsujimoto, A., Tsukahara, T., Numata, N., Miura, S., Sugamura, K., and Nakamura, M.: Molecular mechanisms of promoter regulation of the gp34 gene that is trans-activated by an oncoprotein Tax of human T cell leukemia virus type I. J. Biol. Chem., 273, 14119-14129, 1998.

Sears, R., Ohtani, K. and Nevins, J. R.: Identification of positively and negatively acting elements regulating the expression of the E2F2 gene in response to cell growth signals. Mol. Cell. Biol., 17, 5227-5235, 1997.

Ohtani, K., DeGregori, J., Leone, G., Herendeen, D.R., Kelly, T.J. and Nevins, J. R. : Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol. Cell. Biol., 16, 6977-6984, 1996.

DeGregori, J., Leone, G., Ohtani, K., Alexander Miron and Nevins, J. R : E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes & Dev., 9, 2873-2887, 1995.

Ohtani, K., DeGregori, J. and Nevins, J. R.: Regulation of the cyclin E gene by the E2F1 transcription factor. Proc. Natl. Acad. Sci. USA, 92, 12146-12150, 1995.

Johnson, D.G., Ohtani, K., and Nevins, J. R. : Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes & Dev., 8, 1514-1525, 1994.

Ohtani, K. and Nevins, J. R. : Functional properties of a Drosophila homolog of the E2F1 gene. Mol. Cell. Biol., 14, 1603-1612, 1994.

Tanaka, N., Asao, H., Ohtani, K., Nakamura, M. and Sugamura, K.: A novel human tyrosine kinase gene inducible in T cells by interleukin 2. FEBS Letters, 324, 1-5, 1993.

Takeshita, T., Asao, H., Ohtani, K., Ishii, N., Kumaki, S., Tanaka, N., Munakata, H., Nakamura, M. and Sugamura, K.: Cloning of the g chain of the human IL-2 receptor. Science, 257, 379-382, 1992.

Niki, M., Ohtani, K., Nakamura, M. and Sugamura, K.: Multistep regulation of enhancer activity of the 21-base-pair element of human T-cell leukemia virus type I. J. Virol., 66, 4348-4357, 1992.

Nagata, K., Ide, T.,Takagi, T., Ohtani, K., Aoshima, M., Tozawa, H., Nakamura, M. and Sugamura, K.: Complex formation of human T-cell leukemia virus type I p40tax transactivator with cellular polypeptides. J. Virol., 66, 1040-1049, 1992.

Takeshita, T., Ohtani, K., Asao, H., Kumaki, S., Nakamura, M. and Sugamura, K.: An associated molecule, p64, with IL-2 receptor b chain; Its possible role in the formation of the functional intermediate-affinity IL-2 receptor complex. J. Immunol., 148, 2154-2158, 1992.

Numata, N., Ohtani, K., Niki, M., Nakamura, M., and Sugamura, K.: Synergism between two distinct elements of the HTLV-I enhancer during activation by the trans-activator of HTLV-I. New Biologist, 9, 1-7, 1991.

Miura, S., Ohtani, K., Numata, N., Niki, M., Ohbo, K., Ina, Y., Gojobori T., Tanaka, Y., Tozawa, H., Nakamura, M. and Sugamura, K.: Molecular cloning and characterization of a novel glycoprotein, gp34 that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. Mol. Cell. Biol., 11, 1313-1315, 1991.

Nakamura, M., Niki, M., Nagata, K., Ohtani, K., Saito, S., Hinuma, Y. and Sugamura, K.: Cell line-dependent response of the enhancer element of simian virus 40 to transactivator p40tax encoded by human T-cell leukemia virus type I. J. Biol. Chem., 264, 20189-20192, 1989.

Saito, S., Ando, Y., Furuki, K., Kakimoto, K., Tanigawa, T., Moriyama, I., Ichijo, M., Nakamura, M., Ohtani, K., and Sugamura, K.: Detection of HTLV-I genome in seronegative infants born to HTLV-I seropositive mothers by polymerase chain reaction. Cancer Science, 80, 808-812, 1989.

Nakamura, M., Niki, M., Ohtani, K. and Sugamura, K.: Differential activation of the 21-base-pair enhancer element of human T-cell leukemia virus type I by its own trans-activator and cyclic AMP. Nucleic Acids Res., 17, 5207-5221, 1989.

Nagata, K., Ohtani, K., Nakamura, M. and Sugamura, K.: Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in a human T-cell line Jurkat. J. Virol., 63, 3220-3226, 1989.

Ohtani, K., Nakamura, M., Saito, S., Nagata, K., Sugamura, K. and Hinuma, Y.: Electroporation: application to human lymphoid cell lines for stable introduction of a transactivator gene of human T-cell leukemia virus type I. Nucleic Acids Res., 17, 1589-1604, 1989.

Nakamura, M., Ohtani, K., Hinuma, Y. and Sugamura, K.: Functional mapping of the R region in the HTLV-I long terminal repeat to increase gene expression. Virus Genes, 2, 147-155, 1988.

Saito, S., Nakamura, M., Ohtani, K., Ichijo, M., Sugamura, K. and Hinuma, Y.: trans-Activation of the simian virus 40 enhancer by a pX product of human T-cell leukemia virus type I. J. Virol., 62, 644-648, 1988.

Fujii, M., Nakamura, M., Ohtani, K., Sugamura, K. and Hinuma, Y.: 12-O-tetradecanoylphorbol-13-acetate induces the enhancer function of human T-cell leukemia virus type I. FEBS Letters, 2, 299-303, 1987.

Ohtani, K., Nakamura, M., Saito, S., Noda, T., Ito, Y., Sugamura, K. and Hinuma, Y.: Identification of two distinct elements in the long terminal repeat of HTLV-I responsible for maximum gene expression. EMBO J., 6, 389-395, 1987.

Tamate, E., Sasaki, T., Muryoi T., Takai, O., Otani, K., Tada, K. and Yoshinaga, K.: Expression of idiotype on the surface of human B cells producing anti-DNA antibody. J. Immunol., 136, 1241-1246, 1986.

Books

Komori H, Iwanaga R, Bradford A, Araki K and Ohtani K: Distinct E2F-mediated transcriptional mechanisms in cell proliferation, endoreplication and apoptosis. in “Gene Regulation”, Payam Behzadi ed., InTech Open Access Publisher, 2018. DOI: 10.5772/intechopen.82448

Kurayoshi K, Ozono E, Iwanaga R, Bradford A, Komori H, Araki K and Ohtani K: The key role of E2F in tumor suppression through specific regulation of tumor suppressor genes in response to oncogenic changes. in "Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics", Allan Sebata ed., InTech Open Access Publisher, pp17-43, 2018. ISBN: 978-953-51-3868-6

Ozono E, Yamaoka S and Ohtani K: To grow, stop or die? - Novel tumor-suppressive mechanism regulated by the transcription factor E2F. in "Future Aspects of Tumor Suppressor Gene", Yue Cheng ed., InTech Open Access Publisher, pp17-43, 2013. ISBN 980-953-307-910-8.

Ichwan S, Bakhtiar MT, Ohtani K and Ikeda M: Therapeutic targeting of p53-mediated apoptosis pathway in head and neck squamous cell carcinomas: Current Progress and Challenges. in “Tumor Suppressor Genes”, Yue Cheng ed., InTech Open Access Publisher, pp129-144, 2012. ISBN 978-953-307-879-3

Ohtani K, Komori H, Ozono E, Ikeda M and Iwanaga R: Distinct transcriptional regulation by E2F in cell growth and tumor suppression. in "Control of cellular physiology by the transcription factor E2F", Yoshida, K. ed., Research Signpost, pp91-105. 2008.

Ohtani K and Nakamura M: Molecular mechanism of Tax-mediated cell growth of human T lymphocytes. Gann Monograph on Cancer Research, 50, 43-60, 2003.

Ohtani K: RB, p53 and growth regulation. In “New women's medicine”. Taketani Y. et al. eds. Nakayama Publisher Inc., Vol 41, pp43-58, 2001. (Japanese)

Nakamura M, Ohtani K, Sugamura K and Hinuma Y: Regulation of the promoter activity of human T-cell leukemia virus type I. In "Gene transfer and gene therapy", Verma, I., Mulligan, R. and Beauset, A. eds., Alan R. Liss, Inc., pp103-116, 1989.

Sugamura K, Ohtani K, Nagata K and Nakamura M: Molecular aspects of human retrovirus-induced oncogenesis. In"Current topics in medical virology", Chan, Y. C., Doraisingham, S. and Ling, A. E. eds., World Scientific, pp117-134, 1989.

Reviews

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Zhou Y, Nakajima R, Shirasawa M, Fikriyanti M, Zhao L, Iwanaga R, Bradford A, Kurayoshi K, Araki K, Ohtani K. Expanding roles of the E2F-RB-p53 pathway in tumor suppression. Biology (Basel). 2023 Dec 11;12(12):1511. doi: 10.3390/biology12121511. PMID: 38132337

Nakajima R, Zhao L, Zhou Y, Shirasawa M, Uchida A, Murakawa H, Fikriyanti M, Iwanaga R, Bradford A, Araki K, Warita T and Ohtani K: Deregulated E2F activity as a cancer-cell specific therapeutic tool. Genes, 2023, 14, 393. doi: 10.3390/genes14020393.

Araki K and Ohtani K: New roles of the E2F family in cancer cells - Quality control of the mitochondria by the novel family member E2F3d. Biochemistry, 91, 781-784, 2019. (Japanese)

Ozono E, Bradford A, Iwanaga R, Kurayoshi K, Araki K and Ohtani K: Deregulated E2F activity: Novel targets and therapeutic potential in cancer treatment. International Biology Review, No.3, 2016 (KEI Journals)

Ohtani K and Ozono E: RB/E2F governs replication and stability of chromosomal DNA. Proteins, Nucleic acids and Enzymes, 54, 327-333, 2009. (Japanese)

Iwanaga R and Ohtani K: Perturbance of the cell cycle by HTLV-I Tax. Experimental Medicine, 21, 732-738, 2003. (Japanese)

Ohtani K: Regulatory mechanism of DNA replication factors. Experimental Medicine, 18, 975-981, 2000.

Ohtani K: Implication of transcription factor E2F in regulation of DNA replication. Front. Biosci., 4, d793-804, 1999.

Ohtani K and Nakamura M: How to make genomic and complimentary DNA libraries. Clinical Immunology, 29, 387-399, 1997. (Japanese)

Nakamura M, Takasawa N, Ohbo K, Higashimura N, Ohtani K, Tanaka Y and Sugamura K: HTLV-I Tax trans-activation and cell growth signaling. Leukemia, 11, 7-9, 1997.

Ohtani K and Ikeda M: The transcription factor E2F and the regulation of cell proliferation. Proteins, Nucleic acids and Enzymes, 42, 1603-1611, 1997. (Japanese)

Ohtani K: Regulation of the cell cycle by E2F. Experimental Medicine, 13, 1690-1695, 1995. (Japanese)

Sugamura K, Takeshita T, Asao H, Kumaki S, Ohbo K, Ohtani K and Nakamura M: The IL-2/IL-2 receptor system: involvement of a novel receptor subunit, g chain, in Growth Signal Transduction. Tohoku J. Exp. Med. 168, 231-237, 1992.

Ohtani K and Nakamura M: Cellular target genes of p40tax. Experimental Medicine, 9, 1959-1966, 1991. (Japanese)

Sugamura K, Takeshita T, Asao H, Kumaki S, Ohbo K, Ohtani K and Nakamura M: IL-2-induced signal transduction: Involvement of tyrosine kinase and IL-2 receptor g chain. Lymphokine Research, 9, 539-542, 1990.

Sugamura K, Takeshita T, Nagata K, Goto Y, Asao H, Ohtani K, Nakamura M and Hinuma Y; Roles of HTLV-1 in tumorigenesis of T-cells. Tumors and Viruses. 16, 16-20, 1988. (Japanese)

Invited Oral Presentation

Zhou Y, Nakajima R and Ohtani K: The unique properties of E2F in specifically targeting cancer cells. 20th Annual Congress of International Drug Discovery Science & Technology (China Branch), Shanghai, China, 2024. 9. 12-14.

Nakajima R and Ohtani K: DP-independent E2F activity as a target of cancer specific therapeutics. 20th Annual Congress of International Drug Discovery Science & Technology, Osaka, Japan, 2024. 5, 22-24.

Ohtani K: Deregulated E2F activity: A novel means to discriminate between Cancer cells and normal growing cells. PCS Global Cancer Conference-2014, Athens, Greece, 2014. 11. 1.

Ohtani K: Distinct regulation of tumor suppressor genes by the transcription factor E2F in response to growth stimulation and oncogenic changes. BIT's 6th Annual World Cancer Congress, Xian, China, 2013. 5. 24.